Naturstoff-basierte Arzneimittelentwicklung
Drug Discovery
& Development
Main Research:
Plant-derived antimicrobials
Cranberry (vaccinium macrocarpon)
Studies on the anti-adhesive properties of cranberries and the compounds present in cranberries e.g. proanthocyanidins.
Uropathogenic E. coli (UPEC) carrying different virulence properties serve as test pathogens in a cell culture model of uroepithelial cells.
Hops (Humulus lupulus)
Studies on the antimicrobial effect against bacterial pathogens of the skin including staphylococci, streptococci, propionibacterium spp. Clinical application in dermatology.
Nasturtium (Tropaeolum majus)
Studies on the antimicrobial activity of mustard oils from nasturtium. Elucidation of the mechanisms of action of mustard oils (isothiocyanates) by means of changes in gene activity and protein expression.
Determination of the direct antibacterial effect against oral pathogens and pathogens causing respiratory and urinary tract infections.
Coriander (Coriandrum sativum)
Studies on the antimicrobial activity of virgin coriander essential oil. Clinical application in dermatology.
Horseradish (Armoracia rusticana)
Studies on the antimicrobial activity of horseradish mustard oils. Elucidation of the mechanisms of action of horse- radish mustard oils (isothiocyanates) based on the change in gene activities and protein composition. Determination of the direct antibacterial activity against pathogens causing respiratory and urinary tract infections.
Mistletoe (Viscum album) Studies on anti-infective (immune stimulating) properties: phagocytosis, oxidative burst, intracellular killing.
Mistel (Viscum album)
Studies on anti-infective (immune stimulating) properties: phagocytosis, oxidative burst, intracellular killing.
Purple Coneflower (Echinacea purpurea)
Studies on immunomodulatory properties;
stimulation of T and B cell function and cytokine expression.
South African Geranium (Pelargonium sidoides)
Studies on anti-infective (immune stimulating) properties; phaygocytosis, oxidative burst, intracellular killing.