Naturstoff-basierte Arzneimittelentwicklung

Drug Discovery
& Development



Eichel V, Schüller A, Biehler K, Al-Ahmad A, Frank U. Antimicrobial Effects of Mustard Oil-containing Plants against Oral Pathogens: an in vitro study BMC Complementary Medicine and Therapies. In press.


Weber N, Biehler K, Schwabe K, Haarhaus B, Quirin KW, Frank U, Schempp CM, Wölfle U: Hop Extract acts as an antioxidant with antimicrobial effects against Propionibacterium acnes and Staphylococcus aureus. Molecules, 2019; 24 (2) (online): pii: E223. Online


Biehler K, Frank U: Das antimikrobielle Wirkprinzip pflanzlicher Isothiocyanate (Übersichtsartikel). zaenmagazin (10) 3: 17-20.

Mutters NT, Mampel A, Kropidlowski R, Biehler K, Günther F, Bălu I, Malek V, Frank U: Treating urinary tract infections due to MDR E. coli with Isothiocyanates – a phytotherapeutic alternative to antibiotics? Fitoterapia. 2018 Sep;129:237-240. doi: 10.1016/j.fitote.2018.07.012. Epub 2018 Jul 19. pubmed/30031115


Beikert FC, Anastasiadou Z, Fritzen B, Frank U, Augustin M: Topical treatment of tinea pedis using 6% coriander oil in unguentum leniens: a randomized, controlled, comparative pilot study. Dermatology. 2013;226(1):47-51. Epub 2013 Mar 1. pubmed/23466353

Beikert FC, Schönfeld BS, Frank U, Augustin M: Antiinflammatory potential of seven plant extracts in the ultraviolet erythema test. A randomized, placebo-controlled study. Hautarzt. 2013 Jan;64(1):40-
6. online

Conrad A, Biehler D, Nobis T, Richter H, Engels I, Biehler K, Frank U. (2013) Broad spectrum antibacterial activity of a mixture of isothiocyanates from nasturtium (Tropaeoli majoris herba) and horseradish (Armoraciae rusticanae radix). Drug Res 63: 65-8. pubmed/23447075


Casetti, F., Bartelke, S., Biehler, K., Augustin, M., Schempp, C.M., Frank, U: Antimicrobial activity against bacteria with dermatological relevance and skin tolerance of the essential oil from Coriandrum sativum
L. fruits. Phytother Res 2011; 26: 420-4. online

Janecki, A., Conrad, A., Engels, I., Frank, U., Kolodziej, H: Evaluation of an aqueous-ethanolic extract from Pelargonium sidoides (EPs® 7630) for ist activity against group –streptococci adhesion to human HEp-2 epithelial cells. J Ethnopharmacol, 2011; 133:147-152. pubmed/20883767


Conrad, A., Frank, U. (2008). Extract of Pelargonium sidoides (EPs 7630) displays anti-infective properties by enhanced phagocytosis and differential modulation of host-bacteria interactions. Planta Med. 74(6): 682-5. [ IF: 2]. pubmed/18240106


Conrad A., Kolberg T., Engels I., Frank U. (2006). In-vitro study to evaluate the antibacterial activity of a combination of the haulm of nasturtium (Tropaeoli majoris herba) and the roots of horseradish (Armoraciae rusticanae radix). Arzneimittel-Forschung/Drug Res. 56: 842-849. [ IF: 0,596] pubmed/17260672

Conrad A., Hansmann C., Engels I., Daschner F.D., Frank, U. (2006). Extract of Pelargonium sidoides (EPS® 7630) improves phagocytosis, oxidative burst and intracellular killing of human peripheral blood phagocytes in vitro. Phytomedicine 14 Suppl 6: 46-51. [IF: 1,4] pubmed/17184983


Frank, U., Mutter, J., Schmidt-Eisenlohr, E., Daschner, F.D. (2003). Comparative in vitro activity of piperacillin, piperacillin-sulbactam and piperacillin-tazobactam against nosocomial pathogens isolated from intensive care patients. Clin Microbiol Infect , 9:1128-1132 . pubmed/14616732

Frank, U., Engels, I., Wagner, A., Lacour, M., Daschner, F.D. (2003) Influence of mistletoe (Viscum album) extracts on phagocytosis/burst activity of human phagocytes. Eur J Clin Microbiol Infect Dis. 22: 501-3. online